Don't Put Your Labels On Me

ATRX: Put Me on Repeat

Mutations in the chromatin-remodeling protein ATRX cause alpha thalassaemia and mental retardation, but the severity of the disorder is independent of the specific mutation. In this issue of Cell, Law et al. (2010) demonstrate that ATRX alters gene expression by binding to G-rich tandem repeats, and the degree of transcriptional silencing caused by ATRX mutations correlates with the number of r...

Put your chips on transcriptomics.

The course of any disease is determined by a complex interplay between innate characteristics and environmental triggers. Accordingly, evidence-based risk factor assessment in heart disease requires a detailed family history to gauge inherited features and accurate estimates of smoking, diet, exercise, and other aspects that constitute important extrinsic disease modifiers. The value of traditi...

Put Me in the Sky1

" I thought that I was going to be a doctor, and I majored in science and later in mathematics. But when I got out of college, I decided to study art, " divulged Romare Bearden in a 1968 oral history interview. In New York, " I went to study with George Grosz at the Art Students League. " The German-born artist guided Bearden's understanding of draftsmanship and classical technique, introducing...

Put Your Best

Put your head on my shoulder.